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Research Organics, Inc. is an ISO 9001:2000 primary manufacturer and leading worldwide supplier of high purity biochemicals for use in molecular biology, diagnostics, cell culture, pharmaceuticals, biopharmaceuticals, life sciences and biotechnology. Founded in 1953, Research Organics pioneered manufacture of zwitterionic biological buffers, and developed the HEPES buffer as an industry-standard, white, free-flowing powder that is colorless in solution. In the early 1980s, Research Organics built large-scale production facilities at its Cleveland , Ohio corporate headquarters for bulk manufacture of buffers and biochemicals. Since the 1990s, the company has continuously expanded plant and technical capabilities, adding large-scale process equipment and state-of-the-art facilities.